Gene therapy for restenosis.

نویسندگان

  • M R Kibbe
  • T R Billiar
  • E Tzeng
چکیده

Gene Therapy for Restenosis Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.86.8.829 2000;86:829-833 Circ Res. http://circres.ahajournals.org/content/86/8/829 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circres.ahajournals.org/content/suppl/2000/04/24/86.8.829.DC1.html Data Supplement (unedited) at:

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Gene therapy for restenosis: are we ready?

The application of gene therapy techniques to the clinical problem of coronary restenosis has generated tremendous attention and enthusiasm. Use of gene transfer technology to prevent a common intractable illness would represent a watershed event for human gene therapy. However, the time is not yet right to initiate gene therapy trials for restenosis. The biology of restenosis is incompletely u...

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Gene Therapy for Restenosis: Progress or Frustration?

No systemic pharmacological treatment has been shown to convincingly reduce the incidence of restenosis after angioplasty in patients. The lack of success of many pharmaceutical agents in reducing restenosis rates post-angioplasty and following stent-implementation shown in dozens of clinical trials has encouraged the development of new technological approaches as treatment. Gene therapy has th...

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Despite dramatic technological advances in coronary intervention, restenosis following percutaneous coronary intervention remains an important cause of morbidity with major financial implications. By six months postprocedure, some 16–32% of highly selected patients receiving optimal treatment within the privileged context of a clinical trial have developed restenosis, necessitating target vesse...

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Prospects for gene therapy in cardiovascular disease.

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عنوان ژورنال:
  • Circulation research

دوره 86 8  شماره 

صفحات  -

تاریخ انتشار 2000